A very basic setting issue about spyder and anaconda for python

You can specify the Spyder's Run Settings in Run -> Configure (F6). By default "Execute in current Python or IPython console" is selected and you probably do not have any open console in Spyder.

You can select "Execute in a new dedicated Python console" option and Spyder will automatically open a new console for you. Or you can leave the dafault option and create a new console yourself in the Consoles menu.