Best cross-browser method to capture CTRL+S with JQuery?

This works for me (using jquery) to overload Ctrl+S, Ctrl+F and Ctrl+G:

$(window).bind('keydown', function(event) {
    if (event.ctrlKey || event.metaKey) {
        switch (String.fromCharCode(event.which).toLowerCase()) {
        case 's':
            event.preventDefault();
            alert('ctrl-s');
            break;
        case 'f':
            event.preventDefault();
            alert('ctrl-f');
            break;
        case 'g':
            event.preventDefault();
            alert('ctrl-g');
            break;
        }
    }
});

$(window).keypress(function(event) {
    if (!(event.which == 115 && event.ctrlKey) && !(event.which == 19)) return true;
    alert("Ctrl-S pressed");
    event.preventDefault();
    return false;
});

Key codes can differ between browsers, so you may need to check for more than just 115.

You could use a shortcut library to handle the browser specific stuff.

shortcut.add("Ctrl+S",function() {
    alert("Hi there!");
});