Best way to reduce dwellers in my vault
Release 1.3 now allows you to evict Dwellers.
In the 1.3 release, several new features were added, such as pets, new "pickup lines", and the ability to evict Dwellers, as well as a few other small features.
To evict a Dweller, all you need to do is drag them out to the wasteland, and on the panel used to give them Stimpacks and Rad-Aways before sending them out to explore, is a little red icon; when pressed, will evict the Dweller. Removing them from the roster entirely.
Quick and easy.
Disclaimer: Prepare for feels. The only thing stopping me from hating myself entirely every time I evict a Dweller, is the lack of sad violins playing as they leave the vault.
The times I have had the need to "off" a dweller I just send them into the waste and let them die there. You will have the option to "remove" them once they are dead.
Just remember to send them out without any outfit or weapon.
Rushing a room will eat dwellers much faster than sending them into the wasteland for two hours, and though it only affects 6 dwellers at a time, you can feed more and more dwellers to the 'death room' as they begin to die off. Plus, there's always that ~25% chance that you'll actually get a fresh batch of resources. Either way, once removed, they won't affect happiness.