Calculating a SHA hash with a string + secret key in python

import hmac
import hashlib
import base64

digest = hmac.new(secret, msg=thing_to_hash, digestmod=hashlib.sha256).digest()
signature = base64.b64encode(digest).decode()

I know this sounds silly, but make sure you don't have a trailing space on your secret by accident.

import hmac
import hashlib
import base64
dig = hmac.new(b'1234567890', msg=your_bytes_string, digestmod=hashlib.sha256).digest()
base64.b64encode(dig).decode()      # py3k-mode
'Nace+U3Az4OhN7tISqgs1vdLBHBEijWcBeCqL5xN9xg='

>>> import hmac
>>> import hashlib
>>> import base64
>>> s = """GET
... webservices.amazon.com
... /onca/xml
... AWSAccessKeyId=00000000000000000000&ItemId=0679722769&Operation=ItemLookup&ResponseGroup=ItemAttributes%2COffers%2CImages%2CReviews&Service=AWSECommerceService&Timestamp=2009-01-01T12%3A00%3A00Z&Version=2009-01-06"""
>>> base64.b64encode(hmac.new("1234567890", msg=s, digestmod=hashlib.sha256).digest())
'Nace+U3Az4OhN7tISqgs1vdLBHBEijWcBeCqL5xN9xg='

From http://docs.python.org/library/hashlib.html#module-hashlib (modified a bit):

import hashlib
secretKey = "1234567890"
m = hashlib.sha256()

# Get string and put into givenString.

m.update(givenString + secretKey)
m.digest()