Can I unsubscribe from email chains in Outlook?

Just click the 'Ignore' button...it will auto-delete the thread and any future messages that come in on the same thread. Very quick and efficient for group emails you don't care about.

I'm a little late to the Outlook party, but I found the following workaround which would allow one to achieve this:

• Select Reply All (and mention that you're removing yourself from the thread).
• Go to the Options tab.
• Select Direct Replies To and specify that replies are to be directed to some other user who is currently in the conversation.

Now, all further Reply All-s will have you removed from the recipient list (unless explicitly re-added, of course).

P.S.: This is only when you were initially mentioned explicitly as a recepient. This will not work if you're part of a list present in the recipient field.

You could create a rule that looks for the "all employees" group (I am assuming that its mailing a group) and the RE: in the subject line. That would cover all replies to the original message. However, you run the risk of potentially missing something important.

another possibility would be if you are using an "All Employees" distribution group, the Exchange admins can restrict who can mail to that group.