Can we access GMAIL API using Service Account?

I use the following C# code for accessing Gmail from Service Account

String serviceAccountEmail =
    "999999999-9nqenknknknpmdvif7onn2kvusnqct2c@developer.gserviceaccount.com";

var certificate = new X509Certificate2(
    AppDomain.CurrentDomain.BaseDirectory +
        "certs//fe433c710f4980a8cc3dda83e54cf7c3bb242a46-privatekey.p12",
    "notasecret",
    X509KeyStorageFlags.MachineKeySet | X509KeyStorageFlags.Exportable);

string userEmail = "[email protected]";

ServiceAccountCredential credential = new ServiceAccountCredential(
    new ServiceAccountCredential.Initializer(serviceAccountEmail)
    {
        User = userEmail,
        Scopes = new[] { "https://mail.google.com/" }
    }.FromCertificate(certificate)
);

if (credential.RequestAccessTokenAsync(CancellationToken.None).Result)
{   
    GmailService gs = new GmailService(
        new Google.Apis.Services.BaseClientService.Initializer()
        {
            ApplicationName = "iLink",
            HttpClientInitializer = credential
        }
    );

    UsersResource.MessagesResource.GetRequest gr =
        gs.Users.Messages.Get(userEmail, msgId);
    gr.Format = UsersResource.MessagesResource.GetRequest.FormatEnum.Raw;
    Message m = gr.Execute();

    if (gr.Format == UsersResource.MessagesResource.GetRequest.FormatEnum.Raw)
    {
        byte[] decodedByte = FromBase64ForUrlString(m.Raw);
        string base64Encoded = Convert.ToString(decodedByte);
        MailMessage msg = new MailMessage();
        msg.LoadMessage(decodedByte);
    }
}

Here is a little bit of python 3.7:

from google.oauth2 import service_account
from googleapiclient.discovery import build

def setup_credentials():
    key_path = 'gmailsignatureproject-zzz.json'
    API_scopes =['https://www.googleapis.com/auth/gmail.settings.basic',
                 'https://www.googleapis.com/auth/gmail.settings.sharing']
    credentials = service_account.Credentials.from_service_account_file(key_path,scopes=API_scopes)
    return credentials


def test_setup_credentials():
    credentials = setup_credentials()
    assert credentials


def test_fetch_user_info():
    credentials = setup_credentials()
    credentials_delegated = credentials.with_subject("[email protected]")
    gmail_service = build("gmail","v1",credentials=credentials_delegated)
    addresses = gmail_service.users().settings().sendAs().list(userId='me').execute()
    assert gmail_service

If you want to "read mail" you'll need the newer Gmail API (not the older admin settings API that 'lost in binary' pointed out). Yes you can do this with oauth2 and the newer Gmail API, you need to whitelist the developer in Cpanel and create a key you can sign your requests with--it take a little bit to setup: https://developers.google.com/accounts/docs/OAuth2ServiceAccount#formingclaimset

Yes you can... check the delegation settings...

https://developers.google.com/admin-sdk/directory/v1/guides/delegation#delegate_domain-wide_authority_to_your_service_account

Edit: Use the link Eric DeFriez shared.