Can you loop without crashing?

Pyth, 44 39 bytes

&!eJsM._smm^.j)x"NESW"hdstd:z".\d+"1{IJ

Test suite.

JavaScript, 247 200 bytes

n=s=>{r=s.match(/\w\d+/g)
x=y=z=0
e=""
for(d of r){a=d[0]
b=d.slice(1)
while(b--){
y+=a=="N"
y-=a=="S"
x+=a=="E"
x-=a=="W"
p=[x,y]+";"
if(~e.indexOf(p))if(!x&!y)z++
else return 0
e+=p}}return!x&!y&!z}

n is a function of input string s that returns 1 for true and 0 for false

Here's an ungolfed version for reference/explanation:

function n(s)
{
    var dir = s.match(/\w\d+/g);
    var x = y = z = 0;
    var been = "";
    for (d of dir)
    {
        var a = d[0];
        var b = 1*d.substring(1);
        while(b-- > 0)
        {
            if (a == "N") y++;
            if (a == "S") y--;
            if (a == "E") x++;
            if (a == "W") x--;
            var pt = [x,y] + ";";
            if (~been.indexOf(pt))
                if (x==0 && y==0)
                    z++;
                else
                    return false;
            been += pt;
        }
    }
    return (x == 0 && y==0 && z == 0);
}

n=s=>{r=s.match(/\w\d+/g)
x=y=z=0
e=""
for(d of r){a=d[0]
b=d.slice(1)
while(b--){
y+=a=="N"
y-=a=="S"
x+=a=="E"
x-=a=="W"
p=[x,y]+";"
if(~e.indexOf(p))if(!x&!y)z++
else return 0
e+=p}}return!x&!y&!z}

console.log(n("N1E1S1W1"))
console.log(n("N1E1N1E1S2W2"))
console.log(n("N1S1E1W1"))
console.log(n("N4E2S2W4S2E2"))
console.log(n("N3E2S3"))

Python 3, 236 161 150 bytes

import re
p=0
a=[]
for i in''.join(s[0]*int(s[1:])for s in re.findall(r".\d+",input())):p+=1j**"NESW".find(i);a+=[p]
print(len({*a})-len(a)==0==a[-1])

Try it online!

-75 bytes thanks to Leaky Nun
-11 bytes thanks to Leaky Nun Or, if we're allowed to take input as a list of run length decoded complex numbers:

Python 2, 85 73 bytes

c=0;k=[]
for i in input():c+=i;k+=[c]
print(k[-1]==0==len(set(k))-len(k))

Try it online!

-12 bytes thanks to Mr. Xcoder / -9 bytes thanks to Leaky Nun (merged into one edit)

This feels too long to me lol