Chemistry - Chirality and Optical activity

Of course it will, provided you have a billion of it. (One molecule does not rotate much, after all.) Also, each should come without the rest of the body, or at least without the other hand, otherwise that would make a racemic mixture. (I'll leave the grisly details to the reader's imagination.) Also, each hand should form the same gesture, otherwise the destructive interference will ruin the effect.

Also, light of suitable wavelength would be microwave radiation, and a cursory search seems to indicate that the methods of polarizing it and measuring its polarization are known.

With all these conditions fulfilled, I don't see any difference from the situation with the molecules and ordinary light.