disk I/O error with SQLite3 in Python 3 when writing to a database

I know I might be answering really late, but for others... I had the same problem, and the problem I found was that a python code was already using that database. When I stoped the code and ran the main code again, it did worked..

Setting Backup/Sync to pause on the system tray icon while working with a project stored on Google Drive will prevent disk i/o errors.

This is because when the file is written to or changed, backup & sync attempts to upload the new version to your Google Drive, while it is doing this; the file becomes a 'Read-Only' file.

While sync is paused your Google Drive folder acts more like a normal directory.

(click -> settings -> pause/resume)