Evaluate $\sum_{n,k} \binom{n}{k}^{-1} $

Let $\ell = n -k$, we have

$$\begin{align} \sum_{n=4}^\infty\sum_{k=2}^{n-2} \binom{n}{k}^{-1} &= \sum_{k=2}^\infty\sum_{n=k+2}^\infty \binom{n}{k}^{-1}\\ &= \sum_{k=2}^\infty\sum_{\ell=2}^\infty \binom{k+\ell}{k}^{-1} = \sum_{k=2}^\infty\sum_{\ell=2}^\infty \frac{k!\ell!}{(k+\ell)!}\\ &= \sum_{k=2}^\infty\sum_{\ell=2}^\infty (k+\ell+1)\frac{\Gamma(k+1)\Gamma(\ell+1)}{\Gamma(k+\ell+2)}\\ &= \sum_{k=2}^\infty\sum_{\ell=2}^\infty (k+\ell+1)\int_0^1 t^k (1-t)^\ell dt\\ &= \int_0^1 \sum_{k=2}^\infty\sum_{\ell=2}^\infty \left[ (k+\ell+1) t^k (1-t)^\ell\right] dt \end{align} $$ Notice when $s$ and $t$ are independent, we have

$$\begin{align} \sum_{k=2}^\infty\sum_{\ell=2}^\infty (k+\ell+1)t^k s^\ell = & \sum_{k=2}^\infty\sum_{\ell=2}^\infty \left(t\frac{\partial}{\partial t} + s\frac{\partial}{\partial s} + 1 \right)t^k s^\ell \\ = & \left(t\frac{\partial}{\partial t} + s\frac{\partial}{\partial s} + 1 \right) \frac{t^2s^2}{(1-t)(1-s)}\\ = & \frac{s^2t^2(5-4(s+t)+3st)}{(1-s)^2(1-t)^2} \end{align}$$

Substitute $s$ by $1-t$, we obtain

$$\sum_{k=2}^\infty\sum_{\ell=2}^\infty (k+\ell+1) t^k (1-t)^\ell = 1 + 3t(1-t)$$

As a result,

$$\sum_{n=4}^\infty\sum_{k=2}^{n-2} \binom{n}{k}^{-1} = \int_0^1 (1 + 3t(1-t)) dt = \frac32$$

Generally similar sums can be evaluated using the Beta function: $$ B(x+1,y+1)=\int_0^1 t^{x}(1-t)^{y}dt=\frac{\Gamma(x+1)\Gamma(y+1)}{\Gamma(x+y+2)}= \frac{x!y!}{(x+y+1)!}=\frac{1}{x+y+1}\binom{x+y}x^{-1}. $$

Applying this in your case ($x=n-k,y=k$) one has: $$ \binom{n}{k}^{-1}=(n+1)\int_0^1 t^{n-k}(1-t)^{k}dt $$ or $$\begin{align} I_n=\frac1{n+1}\sum_{k=2}^{n-2}\binom{n}{k}^{-1} &=\sum_{k=2}^{n-2}\int_0^1 t^{n-k}(1-t)^kdt\\ &=\int_0^1\left[ t^n \sum_{k=2}^{n-2}\left(\frac{1-t}t\right)^k\right] dt\\ &=\int_0^1 t^n\left(\frac{1-t}t\right)^2 \frac{1-\left(\frac{1-t}t\right)^{n-3}}{1-\frac{1-t}t}dt\\ \end{align}$$ and, finally, $$\begin{align} \sum_{n=4}^\infty (n+1)I_n& =\int_0^1\left[\frac{(1-t)^2}{2t-1}\sum_{n=4}^\infty (n+1)\left(t^{n-1}-t^2(1-t)^{n-3}\right)\right]dt\\ &=\int_0^1(1+3t-3t^2)dt=\frac32. \end{align}$$

Partial Fractions and Telescoping Sums $$ \begin{align} \sum_{n=4}^\infty\sum_{k=2}^{n-2}\frac1{\binom{n}{k}} &=\sum_{k=2}^\infty\sum_{n=k+2}^\infty\frac1{\binom{n}{k}}\tag1\\ &=\sum_{k=2}^\infty\frac{k}{k-1}\sum_{n=k+2}^\infty\left(\frac1{\binom{n-1}{k-1}}-\frac1{\binom{n}{k-1}}\right)\tag2\\ &=\sum_{k=2}^\infty\frac{k}{k-1}\frac1{\binom{k+1}{k-1}}\tag3\\ &=\sum_{k=2}^\infty\frac2{(k-1)(k+1)}\tag4\\ &=\sum_{k=2}^\infty\left(\frac1{k-1}-\frac1{k+1}\right)\tag5\\[3pt] &=1+\frac12\tag6\\[9pt] &=\frac32\tag7 \end{align} $$ Explanation:
$(1)$: change order of summation
$(2)$: $\frac1{\binom{n-1}{k-1}}-\frac1{\binom{n}{k-1}}=\frac{\frac nk}{\binom{n}{k}}-\frac{\frac{n-k+1}k}{\binom{n}{k}}=\frac{\frac{k-1}k}{\binom{n}{k}}$
$(3)$: telescoping sum
$(4)$: $\binom{k+1}{k-1}=\binom{k+1}{2}=\frac{(k+1)k}2$
$(5)$: partial fractions
$(6)$: telescoping sum
$(7)$: simplify