Galilean transformation of the wave equation

You must first rewrite the old partial derivatives in terms of the new ones. A priori, they're some linear combinations with coefficients that could depend on the spacetime coordinates in general but here they don't depend because the transformation is linear. The rules $$ t'=t, \quad x'=x-Vt,\quad y'=y $$ get translated to $$ \frac{\partial}{\partial t} = \frac{\partial}{\partial t'} - V \frac{\partial}{\partial x'}$$ $$ \frac{\partial}{\partial x} = \frac{\partial}{\partial x'}$$ $$ \frac{\partial}{\partial y} = \frac{\partial}{\partial y'}$$ If you write the coefficients in front of the right-hand-side primed derivatives as a matrix, it's the same matrix as the original matrix of derivatives $\partial x'_i/\partial x_j$. If you don't want to work with matrices, just verify that all the expressions of the type $\partial x/\partial t$ are what they should be if you rewrite these derivatives using the three displayed equations and if you use the obvious partial derivatives $\partial y'/\partial t'$ etc.

If you simply rewrite the (second) derivatives with respect to the unprimed coordinates in terms of the (second) derivatives with respect to the primed coordinates, you will get your second, Galilean-transformed form of the equation. I've verified it works – up to the possible error in the sign of $V$ which only affects the sign of the term with the mixed $xt$ second derivative.

I guess that if this explanation won't be enough, you should re-ask this question on the math forum.

transformation rule for partial derivatives:

$$ \frac{\partial}{\partial x_{\mu}} = \sum_{\nu} \frac{\partial x'_{\nu}}{\partial x_\mu} \frac{\partial}{\partial x'_{\nu}}$$