Hotkey for "This PC"

You can quickly and easily change it:

1. Click View in the menu of File Explorer
2. Click Options at the right side of the ribbon, then Change folder and search options (or simply click the icon above Options)
3. In the dropdown menu next to Open File Explorer to: select This PC
4. Click OK.

I also like the "Quick access" view so I'm not so sure if I want to permanently set "This PC" to the default view when the explorer is opened

In that case you have two options:

1. Get used to simply clicking Quick access in the navigation pane of File Explorer
2. Pin Quick access to the Start menu and assign a custom keyboard shortcut to it:
   
   
   1. Right-click Quick access in File Explorer and click Pin to Start
   2. Right-click Quick access in the Start menu and click Open file location
   3. Right-click the shortcut for Quick access and click Properties
   4. Assign a keyboard shortcut

As for keyboard shortcuts, you can assign shortcuts of the following forms:

• Ctrl + Alt + (key)
• Ctrl + Alt + Shift + (key)
• Function keys (F1, F2 etc.)

If you only press a letter, then the first form is automatically used. If you select a keyboard shortcut that is used for other purposes (such as F1), then your shortcut will either not work, or the functionality of F1 will be overridden by your shortcut.

Probably very late to answer But I was also in the same boat.

one more alternative to @FastEthernet suggestion is:

pin "This PC" to the task bar. and use Win + {number} to open it quickly.

What is {number}? Position of pinned "This PC" on task bar.