How can I configure ReSharper's code cleanup on save?

You could record a macro(Ctrl+E, Ctrl+C,Run, Ctrl+S). Then run that instead of saving. Then all you need to do is assign CTRL+S to your macro.

Public Module RecordingModule
    Sub CLEAN_AND_SAVE()
    DTE.ExecuteCommand ("ReSharper.ReSharper_CleanupCode")
    DTE.ActiveDocument.Save
    End Sub
End Module

This method will show the code clean-up dialogue box where you will have to select Run.

To remove the user interaction you will have to select a profile to run when Code Cleanup is invoked. You can configure this by going into ReSharper | Options | Tools | Code Cleanup and selecting the profile in "Profile to use with silent clean-up" drop down. Its also here where you can create a custom profile to specify what changes to your code to make. In 4.5 however it does not allow you to omit aspx pages. The only differentiator is C# and VB.Net.

Useful link: http://www.jetbrains.com/resharper/features/code_formatting.html

It's my first post (hooray!) so excuse me if it's not perfect in any way...

Question is about R#, but you also mentioned (Visual Studio/ReSharper), so maybe my hint will help somebody. In Visual Studio extension called "Productivity Power Tools" there are two options for this (In Tools -> Options -> Productivity Power Tools -> PowerCommands: General):

1. Format code on save.
2. Remove and Sort Usings on save.

I find PPT nice to have, even with R# installed. You can get them from Visual Studio Gallery (2012 version, but there are also 2010, and 2013 versions).

I just published a free Visual Studio Extension that automates a similar script, for easier setup. You might want to give that a try at http://blog.pedropombeiro.com/keeping-code-formatted-the-easy-way/.