How can I disable the Universal Access Settings icon?

Edit the file /usr/share/gnome-shell/js/ui/panel.js

Comment out this line like so:

//'a11y': imports.ui.status.accessibility.ATIndicator,

Full article here.

There is an extension for that called GNOME Shell noa11y, which removes the Accessibility icon from the GNOME Shell system status area.

more information here.

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