How can I disable 'Use default Gateway for remote networks' setting in Windows 10?

You can use this powershell command to enable/disable default gateway on VPN:

Set-VpnConnection -Name "myVPN" -SplitTunneling $True

If you go to here: %appdata%\Microsoft\Network\Connections\Pbk\rasphone.pbk open with text editor and for every Vpn connection listed change IpPrioritizeRemote=1 – change this to 0 to disable