How can I invert touchpad scroll direction on Windows 10?

I FINALLY figured it out! On my Asus machine, at least. Go to Control Panel, like Browning IT said, but instead of clicking on the "Mouse" option, click on "Asus Smart Gesture" instead. Under the Two Finger Column, check the box next to "Content moves reversely with your finger's direction." I hope this applies to your model. I have a Flip. That took me 2 days to figure out!

If you have a touchpad:

In Windows 10, if you have a touchpad, you will probably have one of the options mentioned in the other answers:

1. Start Menu -> Settings -> Mouse & touchpad -> Reverse scrolling direction

2. Something manufacturer- or device-specific, probably accessible through Control Panel -> Mouse or something similar, as noted in other answers.

If you don't have a touchpad:

(and you want inverse scrolling because, say, like me, you got addicted to it on Mac OS and now find it more natural):

(I don't see why they don't just put a control panel toggle for this, but at least we have a couple of options to make it work):

Registry Setting

There's a registry setting called "FlipFlopWheel" that does this -- (thanks to https://superuser.com/a/364353/153895 by @Richard). This also works as far back as Windows 7, at least (maybe further, I don't know).

HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\HID\VID_???\VID_???\Device Parameters.

There might be multiple mouse entries. The default value for FlipFlopWheel should already be 0. Change it to 1 to invert scrolling. Reboot or replug mouse for changes to take effect.

To get the VID_??? and complete the process you have two options:

1: Manually

Go to the mouse control panel, click the Hardware tab, then click Properties (or, just find the mouse in Device Manager and double-click or right-click Properties)

Either go to the Events tab and look for the VID in the "information" area at bottom, or the Details tab and choose Device instance path in the Property dropdown.

Then you can use Regedit (be careful in there!) to find and change this property:

HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\HID\VID_???\VID_???\Device Parameters

2: Powershell commands

Run this in PowerShell (from Start » All Programs » Accessories » Windows PowerShell):

    # View registry settings
    Get-ItemProperty HKLM:\SYSTEM\CurrentControlSet\Enum\HID\*\*\Device` Parameters FlipFlopWheel -EA 0

    # Change registry settings
    # Reverse mouse wheel scroll FlipFlopWheel = 1 
    # Normal mouse wheel scroll FlipFlopWheel = 0 
    Get-ItemProperty HKLM:\SYSTEM\CurrentControlSet\Enum\HID\*\*\Device` Parameters FlipFlopWheel -EA 0 | ForEach-Object { Set-ItemProperty $_.PSPath FlipFlopWheel 1 }

The command for normal (non-inverted) scrolling has the `0` and `1` swapped:

    # Restore default scroll direction
    Get-ItemProperty HKLM:\SYSTEM\CurrentControlSet\Enum\HID\*\*\Device` Parameters FlipFlopWheel -EA 1 | ForEach-Object { Set-ItemProperty $_.PSPath FlipFlopWheel 0 }

Either way, then just reboot or replug mouse for settings to take effect.

Note: You may find, like I did, that upon unplugging and replugging back into a different USB port, or KVM switch, or something, that it's stopped working, even though the original registry setting is still set.

What happened for me, is that my mouse got a new string/subtree entry in the registry; the beginning (VID_XXXX&PID_XXXX\) are still the same, but the string at the end was different. I had to go into that subtree and set it again for the new instance.

AutoHotkey Script

You can use the following AutoHotkey script:

WheelUp::
Send {WheelDown}
Return

WheelDown::
Send {WheelUp}
Return

(If you have autohotkey installed, simply save the above as an .ahk file, and then double click in Windows Explorer to run it. Your Mileage May Vary. It worked great for me in Windows 8, but am having trouble in Windows 10. Not sure if this is an AutoHotkey/Win 10 issue, or something else.)

Settings > Devices > Mouse & Touchpad > Additional Mouse Options > Devices Settings > Settings > Multi Finger.

Check or uncheck 'Reverse Scrolling Direction' .

This works on Lenovo Y410P