How can I run an external command asynchronously from Python?

If you want to run many processes in parallel and then handle them when they yield results, you can use polling like in the following:

from subprocess import Popen, PIPE
import time

running_procs = [
    Popen(['/usr/bin/my_cmd', '-i %s' % path], stdout=PIPE, stderr=PIPE)
    for path in '/tmp/file0 /tmp/file1 /tmp/file2'.split()]

while running_procs:
    for proc in running_procs:
        retcode = proc.poll()
        if retcode is not None: # Process finished.
            running_procs.remove(proc)
            break
        else: # No process is done, wait a bit and check again.
            time.sleep(.1)
            continue

    # Here, `proc` has finished with return code `retcode`
    if retcode != 0:
        """Error handling."""
    handle_results(proc.stdout)

The control flow there is a little bit convoluted because I'm trying to make it small -- you can refactor to your taste. :-)

This has the advantage of servicing the early-finishing requests first. If you call communicate on the first running process and that turns out to run the longest, the other running processes will have been sitting there idle when you could have been handling their results.

subprocess.Popen does exactly what you want.

from subprocess import Popen
p = Popen(['watch', 'ls']) # something long running
# ... do other stuff while subprocess is running
p.terminate()

(Edit to complete the answer from comments)

The Popen instance can do various other things like you can poll() it to see if it is still running, and you can communicate() with it to send it data on stdin, and wait for it to terminate.