How do I remedy "The breakpoint will not currently be hit. No symbols have been loaded for this document." warning?

Start debugging, as soon as you've arrived at a breakpoint or used Debug > Break All, use Debug > Windows > Modules. You'll see a list of all the assemblies that are loaded into the process. Locate the one you want to get debug info for. Right-click it and select Symbol Load Information. You'll get a dialog that lists all the directories where it looked for the .pdb file for the assembly. Verify that list against the actual .pdb location. Make sure it doesn't find an old one.

In normal projects, the assembly and its .pdb file should always have been copied by the IDE into the same folder as your .exe, i.e. the bin\Debug folder of your project. Make sure you remove one from the GAC if you've been playing with it.

Check if you are not in release but in Debug.

When in debug:

First try rebuilding your project by right mouse click the project > Rebuild If that doesn't work, try a clean of the project (right mouse click on the project > clean)

If that didn't work check this:

1. Right mouse click your project
2. Select [Properties]
3. Select the [Build] tab
4. Make sure [Define DEBUG constant] and [Define TRACE constant] are checked
5. Make sure [Optimize Code] is unchecked
6. Click the [Advanced] button at the bottom of the Build tabpage
7. Make sure that [Debug Info:] is set to [full]
8. Click [OK] and rebuild the project ;-)

(step 6 generates the .pdb files, these are the debugging symbols)

Just something simple to try - you may have tried it already. Right click the Solution in solution explorer, click "clean solution", this deletes all the compiled and temporary files associated with a solution.

Do a rebuild of the solution and try to debug again.

I've also had troubles with breakpoints multiple projects in a solution - some compiled as x86, some as x64.