How do I resolve this error, "ERROR 1298 (HY000): Unknown or incorrect time zone: 'UTC'"?

Simply run mysql_tzinfo_to_sql /usr/share/zoneinfo | mysql -u root mysql -p

$ mysql_tzinfo_to_sql /usr/share/zoneinfo | mysql -u root mysql -p
Enter password: 
Warning: Unable to load '/usr/share/zoneinfo/iso3166.tab' as time zone. Skipping it.
Warning: Unable to load '/usr/share/zoneinfo/leap-seconds.list' as time zone. Skipping it.
Warning: Unable to load '/usr/share/zoneinfo/zone.tab' as time zone. Skipping it.
Warning: Unable to load '/usr/share/zoneinfo/zone1970.tab' as time zone. Skipping it.

Trivia: If you want to know what the HY00 stands for (a follow up I asked years later)....

As kaiser suggested, the trailing slash is unneeded but without specifying mysql as the database mariadb complains about a missing database. I found that

$ mysql_tzinfo_to_sql /usr/share/zoneinfo | mysql -u root -p -Dmysql

was the correct way to solve the problem in Mariadb 164.