How do I use AND in a Django filter?

For thoroughness sake, let's just mention the Q object method:

from django.db.models import Q
criterion1 = Q(question__contains="software")
criterion2 = Q(question__contains="java")
q = Question.objects.filter(criterion1 & criterion2)

Note the other answers here are simpler and better adapted for your use case, but if anyone with a similar but slightly more complex problem (such as needing "not" or "or") sees this, it's good to have the reference right here.

(update: this answer will not work anymore and give the syntax error keyword argument repeated)

mymodel.objects.filter(first_name__icontains="Foo", first_name__icontains="Bar")

update: Long time since I wrote this answer and done some django, but I am sure to this days the best approach is to use the Q object method like David Berger shows here: How do I use AND in a Django filter?