How to change the C++ Runtime Library setting in QtCreator?

/MT is a compiler flag. You can specify flags in your .pro file like this:

QMAKE_CXXFLAGS += /MT

Moreover, you probably want to specify /MTd for debug build:

Release:QMAKE_CXXFLAGS += /MT
Debug:QMAKE_CXXFLAGS += /MTd

In the version of QT 5.5 the variable is QMAKE_CXXFLAGS_DEBUG and QMAKE_CXXFLAGS_RELEASE so the new working solution for QT 5.5 is:

QMAKE_CXXFLAGS_DEBUG += /MTd
QMAKE_CXXFLAGS_RELEASE += /MT

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