How to characterize $E_n$ morphisms from $\mathrm{Mod}(A)$ to $\mathrm{Mod}(B)$?

By Corollary HA.4.8.5.20, the functor from $\mathbb{E}_{n+1}$-algebras to $\mathbb{E}_n$-monoidal categories and colimit-preserving, $\mathbb{E}_n$-monoidal functors is fully faithful. (Notice that the condition of being "linear over Sp" is automatic from exactness). So, indeed, you'd get just $\mathbb{E}_{n+1}$-algebra maps $A \to B$.

Added:

I just wrote down the reference, but of course, as Ben-Zvi points out, this should be relatively intuitive. First of all, building a functor $F:\mathsf{RMod}_A \to \mathcal{C}$ means that I'd better tell you how $A=\mathrm{End}_A(A)$ acts on $F(A)$, and you can kinda see that that is all I need to do if $F$ commutes with colimits (because I can start resolving by free modules and I understand what to do with all the maps). In other words, I need to provide an algebra map $A \to \mathrm{End}_{\mathcal{C}}(F(A))$. So now we believe that $A \mapsto \mathsf{RMod}_A$, viewed as a functor to categories equipped with a distinguised object, has a right adjoint given by $(\mathcal{C},c)\mapsto \mathrm{End}(c)$.

The functor $A \mapsto \mathsf{RMod}_A$ turns out to be symmetric monoidal when one views its values as landing in, say, stable, presentable categories, and so its right adjoint will be lax symmetric monoidal. It follows that we get an induced adjunction on categories of algebras, and that the endomorphism object of the unit in an $\mathbb{E}_n$-monoidal category is canonically $\mathbb{E}_{n+1}$-monoidal (you can think of that like: you get an $\mathbb{E}_1$-algebra structure from composing, and then an $\mathbb{E}_n$-algebra structure from tensoring, so together you get an $\mathbb{E}_{n+1}$-algebra structure).

All together, then, to specify an $\mathbb{E}_n$-monoidal functor $\mathsf{RMod}_A \to \mathcal{C}$, I just need an $\mathbb{E}_{n+1}$-algebra map $A \to \mathrm{End}_{\mathcal{C}}(1)$.

There's some other discussion about how to describe maps between categories of $\mathbb{E}_n$-modules, but I think that's not as clear to me... Yes, it's true that the endomorphisms of the unit in the category of $\mathbb{E}_n$-modules is the $\mathbb{E}_n$-center, but if the source of our functor is some other category of $\mathbb{E}_n$-modules (as opposed to ordinary modules over something $\mathbb{E}_{n+1}$), then our argument above doesn't apply.