How to clear MemoryCache?

Dispose the existing MemoryCache and create a new MemoryCache object.

The problem with enumeration

The MemoryCache.GetEnumerator() Remarks section warns: "Retrieving an enumerator for a MemoryCache instance is a resource-intensive and blocking operation. Therefore, the enumerator should not be used in production applications."

Here's why, explained in pseudocode of the GetEnumerator() implementation:

Create a new Dictionary object (let's call it AllCache)
For Each per-processor segment in the cache (one Dictionary object per processor)
{
    Lock the segment/Dictionary (using lock construct)
    Iterate through the segment/Dictionary and add each name/value pair one-by-one
       to the AllCache Dictionary (using references to the original MemoryCacheKey
       and MemoryCacheEntry objects)
}
Create and return an enumerator on the AllCache Dictionary

Since the implementation splits the cache across multiple Dictionary objects, it must bring everything together into a single collection in order to hand back an enumerator. Every call to GetEnumerator executes the full copy process detailed above. The newly created Dictionary contains references to the original internal key and value objects, so your actual cached data values are not duplicated.

The warning in the documentation is correct. Avoid GetEnumerator() -- including all of the answers above that use LINQ queries.

A better and more flexible solution

Here's an efficient way of clearing the cache that simply builds on the existing change monitoring infrastructure. It also provides the flexibility to clear either the entire cache or just a named subset and has none of the problems discussed above.

// By Thomas F. Abraham (http://www.tfabraham.com)
namespace CacheTest
{
    using System;
    using System.Diagnostics;
    using System.Globalization;
    using System.Runtime.Caching;

    public class SignaledChangeEventArgs : EventArgs
    {
        public string Name { get; private set; }
        public SignaledChangeEventArgs(string name = null) { this.Name = name; }
    }

    /// <summary>
    /// Cache change monitor that allows an app to fire a change notification
    /// to all associated cache items.
    /// </summary>
    public class SignaledChangeMonitor : ChangeMonitor
    {
        // Shared across all SignaledChangeMonitors in the AppDomain
        private static event EventHandler<SignaledChangeEventArgs> Signaled;

        private string _name;
        private string _uniqueId = Guid.NewGuid().ToString("N", CultureInfo.InvariantCulture);

        public override string UniqueId
        {
            get { return _uniqueId; }
        }

        public SignaledChangeMonitor(string name = null)
        {
            _name = name;
            // Register instance with the shared event
            SignaledChangeMonitor.Signaled += OnSignalRaised;
            base.InitializationComplete();
        }

        public static void Signal(string name = null)
        {
            if (Signaled != null)
            {
                // Raise shared event to notify all subscribers
                Signaled(null, new SignaledChangeEventArgs(name));
            }
        }

        protected override void Dispose(bool disposing)
        {
            SignaledChangeMonitor.Signaled -= OnSignalRaised;
        }

        private void OnSignalRaised(object sender, SignaledChangeEventArgs e)
        {
            if (string.IsNullOrWhiteSpace(e.Name) || string.Compare(e.Name, _name, true) == 0)
            {
                Debug.WriteLine(
                    _uniqueId + " notifying cache of change.", "SignaledChangeMonitor");
                // Cache objects are obligated to remove entry upon change notification.
                base.OnChanged(null);
            }
        }
    }

    public static class CacheTester
    {
        public static void TestCache()
        {
            MemoryCache cache = MemoryCache.Default;

            // Add data to cache
            for (int idx = 0; idx < 50; idx++)
            {
                cache.Add("Key" + idx.ToString(), "Value" + idx.ToString(), GetPolicy(idx));
            }

            // Flush cached items associated with "NamedData" change monitors
            SignaledChangeMonitor.Signal("NamedData");

            // Flush all cached items
            SignaledChangeMonitor.Signal();
        }

        private static CacheItemPolicy GetPolicy(int idx)
        {
            string name = (idx % 2 == 0) ? null : "NamedData";

            CacheItemPolicy cip = new CacheItemPolicy();
            cip.AbsoluteExpiration = System.DateTimeOffset.UtcNow.AddHours(1);
            cip.ChangeMonitors.Add(new SignaledChangeMonitor(name));
            return cip;
        }
    }
}