How to create a GUID/UUID using iOS

[[UIDevice currentDevice] uniqueIdentifier]

Returns the Unique ID of your iPhone.

EDIT: -[UIDevice uniqueIdentifier] is now deprecated and apps are being rejected from the App Store for using it. The method below is now the preferred approach.

If you need to create several UUID, just use this method (with ARC):

+ (NSString *)GetUUID
{
  CFUUIDRef theUUID = CFUUIDCreate(NULL);
  CFStringRef string = CFUUIDCreateString(NULL, theUUID);
  CFRelease(theUUID);
  return (__bridge NSString *)string;
}

EDIT: Jan, 29 2014: If you're targeting iOS 6 or later, you can now use the much simpler method:

NSString *UUID = [[NSUUID UUID] UUIDString];

Here is the simple code I am using, compliant with ARC.

+(NSString *)getUUID
{
    CFUUIDRef newUniqueId = CFUUIDCreate(kCFAllocatorDefault);
    NSString * uuidString = (__bridge_transfer NSString*)CFUUIDCreateString(kCFAllocatorDefault, newUniqueId);
    CFRelease(newUniqueId);

    return uuidString;
}

In iOS 6 you can easily use:

NSUUID  *UUID = [NSUUID UUID];
NSString* stringUUID = [UUID UUIDString];

More details in Apple's Documentations