how to disable pdb.set_trace() without stopping python program and edit the code

to my knowledge, you could not bypass set_trace, but you could neutralize it, once debugger stopped, type:

pdb.set_trace = lambda: 1

then continue, it wont break again.

Setting a breakpoint (requires Python 3.7):

breakpoint()

Disabling breakpoints set with the breakpoint() function:

import os
os.environ["PYTHONBREAKPOINT"] = "0"

Long story:

In the 3.7 version of Python, the breakpoint() built-in function for setting breakpoints was introduced. By default, it will call pdb.set_trace(). Also, since the 3.7 version of Python the PYTHONBREAKPOINT environment variable is available. It is considered when the breakpoint() function is used.
So, in order to disable these breakpoints (set with the breakpoint() function), one can just set the PYTHONBREAKPOINT environment variable like this:

import os
os.environ["PYTHONBREAKPOINT"] = "0"

It may be useful to mention here sys.breakpointhook() which was also added in the 3.7 version of Python and allows to customize breakpoints behavior.