How to disable the screen orientation hotkeys in Windows (XP)?

I have not tested on AMD/ATI graphics, but I know for a fact that all Intel drivers do this and some Nvidia drivers.

Simply go in to the configuration tool of your driver and look under a section called hotkeys and disable it.

For Intel:

Looks like the answer is to right-click your desktop, select Graphics Options >>> Hot Keys >>> Disable.

Though see here, where someone describes doing this, having it work for a while, and then having an update borking it for them. Others have suggested in a worst-case like this to uninstall the configuration software installed with your driver but to keep the driver. I'm a little anxious that that's not an nVidia fix, though, since you have to use the above route to disable them in the first place, not some sort of control panel.

In any event, the Graphics Options route worked for me in a similar situation.

If disable the Intel driver hotkey feature is not usefull, you can try to change the hotkey and then disable it. On my computer, this method works.