How to prevent or block closing a WinForms window?

private void Form1_FormClosing(object sender, FormClosingEventArgs e) {
    var window = MessageBox.Show(
        "Close the window?", 
        "Are you sure?", 
        MessageBoxButtons.YesNo);

    e.Cancel = (window == DialogResult.No);
}

Catch FormClosing event and set e.Cancel = true

private void AdminFrame_FormClosing(object sender, FormClosingEventArgs e)
{
    var res = MessageBox.Show(this, "You really want to quit?", "Exit",
            MessageBoxButtons.YesNo, MessageBoxIcon.Warning, MessageBoxDefaultButton.Button2);
    if (res != DialogResult.Yes)
    {
      e.Cancel = true;
      return;
    }
}

A special twist might be to always prevent just the user closing the form:

private void Frm_FormClosing(object sender, FormClosingEventArgs e)
{
    e.Cancel = (e.CloseReason == CloseReason.UserClosing); 
    // disable user closing the form, but no one else
}