Ignore milliseconds when comparing two datetimes

Care should be taken, if dt has non-zero microseconds (fractions of millis). Setting only milliseconds to zero is not enough.
To set millis and below to zero (and get a succesfull comparison), the code would be:

dt = dt.AddTicks(-dt.Ticks % TimeSpan.TicksPerSecond); // TimeSpan.TicksPerSecond=10000000

TimeSpan difference = dtNew - dtOrig;
if (difference >= TimeSpan.FromSeconds(1))
{
    ...
}

Create a new DateTime value with the milliseconds component set to 0:

dt = dt.AddMilliseconds(-dt.Millisecond);

I recommend you use an extension method:

public static DateTime TrimMilliseconds(this DateTime dt)
{
    return new DateTime(dt.Year, dt.Month, dt.Day, dt.Hour, dt.Minute, dt.Second, 0, dt.Kind);
}

then its just:

if (dtOrig.TrimMilliseconds() == dtNew.TrimMilliseconds())