ImportError: No module named MySQLdb

Or try this:

apt-get install python-mysqldb

If you're having issues compiling the binary extension, or on a platform where you cant, you can try using the pure python PyMySQL bindings.

Simply pip install pymysql and switch your SQLAlchemy URI to start like this:

SQLALCHEMY_DATABASE_URI = 'mysql+pymysql://.....'

There are some other drivers you could also try.