2D animation in Python

You can try pygame, its very easy to handle and similar to SDL under c++

Arcade works on any platform with OpenGL 3.3+ (i.e. not the Raspberry Pi, but most other platforms). Although it's intended for simple games, Arcade offers great bitmap and sprite handling, as well as simple graphics primitives such as rectangles, arcs and circles.

I am a fan of pyglet which is a completely self contained library for doing graphical work under win32, linux, and OS X.

It has very low overhead, and you can see this for yourself from the tutorial on the website. It should play well with wxpython, or at least I seem to recall posts to the mailing list about wxpython and pyglet being used together.

It however does not offer selection of objects via mouse clicks - this you will have to handle yourself. Generally speaking for a 2D application this is not too difficult to do.

mactorii is an OS X application of mine written in pure python+pyglet, and has some basic animation (scrolling) and click detection. It doesn't use wxpython, but perhaps it will give you an idea of what is involved. Note however mactorii is using the old pyglet api, so the run loop I have in there is obsolete. I will get around to updating it one day... :P