Break when a value changes using the Visual Studio debugger

You can also choose to break explicitly in code:

// Assuming C#
if (condition)
{
    System.Diagnostics.Debugger.Break();
}

From MSDN:

Debugger.Break: If no debugger is attached, users are asked if they want to attach a debugger. If yes, the debugger is started. If a debugger is attached, the debugger is signaled with a user breakpoint event, and the debugger suspends execution of the process just as if a debugger breakpoint had been hit.

This is only a fallback, though. Setting a conditional breakpoint in Visual Studio, as described in other comments, is a better choice.

In the Visual Studio 2005 menu:

Debug -> New Breakpoint -> New Data Breakpoint

Enter:

&myVariable