Breakpoint Failed to Bind - Visual Studio 2015

I had the same problem.

I solved it disabling "Optimize code" option in project properties Build tab.

I had the same problem but a different solution. Please note I updated to VS 2015 Update 1 and the problem is still there.

In previous edition of VS starting debug automatically triggered a build in debug mode. But with VS2015 it does not.

So if your last build was in release mode, and you try debugging, breakpoint won't work.

You have to manually build in debug mode first, then start debugging.