Can I run SignalR hub through Azure API Management?

websocket is currently not supported in Azure API Management. Please feel free to raise a feature request: http://feedback.azure.com/forums/248703-api-management/filters/new

It depends, websockets are not supported, but if you use an azure signalr ressource, only the negotiate request,; which is a basic post to your hub, has to go through your APIM, and the rest of the coms (the websocket requests) will be directly with the azure signalr ressource.