Concatenating two lists - difference between '+=' and extend()

You can't use += for non-local variable (variable which is not local for function and also not global)

def main():
    l = [1, 2, 3]

    def foo():
        l.extend([4])

    def boo():
        l += [5]

    foo()
    print l
    boo()  # this will fail

main()

It's because for extend case compiler will load the variable l using LOAD_DEREF instruction, but for += it will use LOAD_FAST - and you get *UnboundLocalError: local variable 'l' referenced before assignment*

The only difference on a bytecode level is that the .extend way involves a function call, which is slightly more expensive in Python than the INPLACE_ADD.

It's really nothing you should be worrying about, unless you're performing this operation billions of times. It is likely, however, that the bottleneck would lie some place else.