Does the mass lost by merging black holes depend on how they merged?

Yes. The amount of energy radiated as gravitational waves will depend on the details of the two black holes before the merger. The answers to questions like:

• Was the orbit circular or elliptical?
• Were they spinning?
• Were the spins of the black holes aligned with the orbital plane?

will affect the energy of the gravitational waves. The most import detail in terms of energy radiated is the mass ratio of the two precursor black holes.

The final mass of the system $M_\mathrm{fin}$ is always less than the original total mass ($m_1 + m_2$), since some of the mass energy gets converted to gravitational waves, $M_\mathrm{rad}$.

$$M_\mathrm{fin} + M_\mathrm{rad} = m_1 + m_2 $$

Because of something akin to the second law of thermodynamics the final black hole must be bigger than the biggest original black hole. Basically, you can't radiate so much energy in gravitational waves that a black hole shrinks.

$$M_\mathrm{fin} > m_1 \quad \mathrm{and} \quad M_\mathrm{fin} > m_2$$

We can define the fraction of mass radiated aways as:

$$ e = \frac{M_\mathrm{rad}}{m_1 + m_2} $$

This is sometimes called the efficiency of radiation.

If the black holes have about the same mass (as they did in the LIGO detection), about 5% of the total mass will be radiated away. This is the most efficient possibility.

On the other extreme imagine the case where one black hole is way more massive than the other: maybe 1 million solar masses and 1 solar mass. In order to follow the two rules stated above, $M_\mathrm{fin}$ is less than 1 million and one solar masses and greater than 1 million solar masses. In this case the efficiency would be about $e=10^{-6}$ or 0.0001%. Extreme mass ratios produce the weakest gravitational waves.