Drawing enzyme with TikZ
I'd use pics for that. This allows you to draw the same thing, possibly with some variation, over and over. In this example, I use
\draw (1.2,2.9) pic[rotate=25] {Enzyme B=3};
Here, Enzyme B is the second of your enzymes, and 3 means both receptors (?) are filled. If I would had chosen 0, 1 or 2 instead, none, the lower one or the upper one would have been filled. (1.2,2.9) is the coordinate, and as you see, you can rotate the pic (or subject it to other transformations like scale for instance). I have left a few enzymes to be placed for you as an exercise. ;-) (EDIT: Made the radii of the bummies a bit smaller and adjustable.)
\documentclass[tikz, margin=3.14mm]{standalone}
\pgfkeys{tikz/.cd,
bummy radius/.store in=\BummyRadius,
bummy radius=1.6mm
}
\tikzset{pics/.cd,
Enzyme A/.style={
code={
\draw[thin,fill=green!30] (0.3,0) arc(90:270:0.15) -- (0.3,-0.3) to[out=-90,in=0] (0,-0.5)
to[out=180,in=-90] (-0.3,-0.3) to (-0.3,0.3) to[out=90,in=180] (0,0.5)
to[out=0,in=90] (0.3,0.3) arc(90:270:0.15) --cycle;
\ifnum#1=1
\fill[red!80] (1.1mm+\BummyRadius,-0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,-0.21) circle (\BummyRadius);
\fi
\ifnum#1=2
\fill[red!80] (1.1mm+\BummyRadius,0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,0.21) circle (\BummyRadius);
\fi
\ifnum#1=3
\fill[red!80] (1.1mm+\BummyRadius,-0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,-0.21) circle (\BummyRadius);
\fill[red!80] (1.1mm+\BummyRadius,0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,0.21) circle (\BummyRadius);
\fi
}
},
Enzyme B/.style={
code={
\draw[thin,fill=green!30] (0.3,-0.02) -- (0.1,-0.02) |- (0.3,-0.4)
|- (-0.3,-0.5) |- (0.3,0.5) |- (0.1,0.4) |- (0.3,0.02) -- cycle;
\ifnum#1=1
\fill[red!80] (1.1mm+\BummyRadius,-0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,-0.21) circle (\BummyRadius);
\fi
\ifnum#1=2
\fill[red!80] (1.1mm+\BummyRadius,0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,0.21) circle (\BummyRadius);
\fi
\ifnum#1=3
\fill[red!80] (1.1mm+\BummyRadius,-0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,-0.21) circle (\BummyRadius);
\fill[red!80] (1.1mm+\BummyRadius,0.21) circle (\BummyRadius) (1.1mm+2.8*\BummyRadius,0.21) circle (\BummyRadius);
\fi
}
},
}
\begin{document}
\begin{tikzpicture}
\draw[blue!40,ultra thick] plot[domain=-7.5:7.5,variable=\x,smooth,samples=50]
(\x,{tanh(\x/1.5)+3*exp(-0.5*\x*\x)});
\foreach \X in {-2.5,2.5}
{\draw[thick,dashed] (\X,-1) -- (\X,8);}
% left panel
\foreach \X in {0,1.5}
{\foreach \Y in {1,...,5}
{\draw (\X-7+0.1*rand,1.5*\Y+0.1*rand) pic[rotate=rand*20] {Enzyme A=0};}}
\draw (-3.3,6.8) pic[rotate=rand*20] {Enzyme B=0};
\draw (-3.4,5.3) pic[rotate=rand*20] {Enzyme B=0};
% middle
\foreach \X in {0,1.25}
{\foreach \Y [evaluate=\Y as \Z using {int(5-\Y)}]in {3,4,5}
{\draw (\X-2+0.1*rand,1.5*\Y+0.1*rand) pic[rotate=rand*20] {Enzyme A=\Z};}}
\draw (-1.2,2.8) pic {Enzyme A=3};
\foreach \X in {0,1.25}
{\foreach \Y [evaluate=\Y as \Z using {int(5-\Y)}]in {3,4,5}
{\draw (\X+0.75+0.1*rand,1.5*\Y+0.1*rand) pic[rotate=rand*20] {Enzyme B=\Z};}}
\draw (1.2,2.9) pic[rotate=25] {Enzyme B=3};
% right panel
\foreach \X in {0,1.5}
{\foreach \Y in {1,...,5}
{\draw (\X+5.5+0.1*rand,1.25*\Y+1+0.1*rand) pic[rotate=rand*20] {Enzyme B=3};}}
\draw (3.3,6.8) pic[rotate=rand*20] {Enzyme A=3};
\draw (3.4,5.3) pic[rotate=rand*20] {Enzyme A=3};
\end{tikzpicture}
\end{document}
just for fun and recognizing that marmot's code is really practical, a version with other options that require manual positioning, to get the result as close to the example; the enzymes have conditional parts derived from marmot's answer, but these are activated or deactivated with 0 or 1 to avoid defining 4 states.
RESULT:
MWE:
\documentclass[border=0pt]{standalone}
\usepackage{tikz}
\definecolor{mygreen}{HTML}{BED395}
\definecolor{myblue}{HTML}{87ABEC}
\definecolor{linegreen}{HTML}{989F7F}
\definecolor{color1}{HTML}{DFD8C8}
\begin{document}
\pagecolor{color1}
\begin{tikzpicture}
\def\activator(#1){
\begin{scope}[shift={(#1)}]
\draw[line width=1pt,linegreen,fill=red](0,0)
arc (180:40:0.15) arc (140:0:0.15) arc (0:-140:0.15) arc (-40:-180:0.15);
\end{scope}
}
\def\enzymeA(#1)[#2]#3#4{
\begin{scope}[shift={(#1)},rotate=#2]
\draw[linegreen,fill=mygreen,line width=1pt] (-0.5,0.76)
-| ++ (1,-0.3) -| ++ (-0.4,-0.4) -| ++ (0.4,-0.12) -| ++ (-0.4,-0.4) -| ++ (0.4,-0.3) -| cycle;
\ifnum#3=1 \activator(0.3,0.26) \fi
\ifnum#4=1 \activator(0.3,-0.26) \fi
\end{scope}
}
\def\enzymeB(#1)[#2]#3#4{
\begin{scope}[shift={(#1)},rotate=#2]
\draw[linegreen,fill=mygreen,line width=1pt](-0.5,0.76-0.3)
arc (180:90:0.3) -- ++ (0.4,0) arc (90:0:0.3) arc (90:270:0.22) -- ++ (0,-0.05) arc (90:270:0.22)
arc (0:-90:0.3) -- ++ (-0.4,0) arc (-90:-180:0.3) -| cycle;
\ifnum#3=1 \activator(0.4,0.24) \fi
\ifnum#4=1 \activator(0.4,-0.25) \fi
\end{scope}
}
%Start drawing the thing
\draw[myblue,line width=3pt]
(1.5,0)
to [out=0, in=180,out looseness=1.8,in looseness=0.4] ++(9,6)
to [out=0, in=180,out looseness=0.4,in looseness=2] ++(9,-4);
\draw[dash pattern = on 10pt off 10pt, very thick](0,0)++(6,0) -- ++(0,14);
\draw[dash pattern = on 10pt off 10pt, very thick](6,0)++(9,0) -- ++(0,14);
%Draw void enzymes B
\foreach \x/\y/\rotation in {
0/4/-5,
1.5/5/10,
3/4/10,
0.2/6/-15,
2/7/10,
3.5/6/-15,
0.2/8/5,
1.5/9/5,
0.1/10/-10,
1.5/11/26,
0.2/12/-10,
1.7/13/10,
7/12/26,
9/13/-10
}
{
\enzymeB(\x,\y)[\rotation]{0}{0}
}
%Draw activated enzymes B
\foreach \x/\y/\rotation in {
8/6/-20,
16/10/15,
16/12/-15
}
{
\enzymeB(\x,\y)[\rotation]{1}{1}
}
%Draw void enzymes A
\foreach \x/\y/\rotation in {
5/9/10,
4.5/11/-5,
13/13/-15
}
{
\enzymeA(\x,\y)[\rotation]{0}{0}
}
%Draw activated enzymes A
\foreach \x/\y/\rotation in {
20/3.5/-15,
18.2/3.5/26,
20/5.4/15,
18.5/5.4/10,
19.2/7.3/-5,
17.7/7.1/-5,
19.7/9.1/-15,
18/9/10,
20./11/15,
18.2/11/-5,
20/13/15,
18.2/13/-15,
14/5.4/-10,
12.5/6.2/26
}
{
\enzymeA(\x,\y)[\rotation]{1}{1}
}
%Incomplete activation enzymes
\enzymeB(7,8)[26]{0}{1}
\enzymeB(7,10)[-15]{0}{1}
\enzymeB(9,8.5)[15]{1}{0}
\enzymeB(9,10.5)[-15]{0}{1}
\enzymeA(12,11)[15]{1}{0}
\enzymeA(14,11)[-15]{0}{1}
\enzymeA(12,8.5)[15]{1}{0}
\enzymeA(14,8.5)[-26]{0}{1}
\end{tikzpicture}
\end{document}
Since that is just a very quick answer, here are just the “styles“ that are necessary:
\documentclass[border=5pt,tikz]{standalone}
\begin{document}
\begin{tikzpicture}[green!70!black]
\begin{scope}[rotate=75]
\draw (0,0) arc(0:180:.5);
\draw (1,0) arc(0:180:.5);
\draw (-1.5,.5) arc(180:270:.5);
\draw (-1.5,.5) --+ (0,.5) arc(-180:-270:.5) --+ (2,0);
\draw (1.5,1) arc(0:90:.5);
\draw (1.5,1) --+ (0,-.5) arc(0:-90:.5);
\end{scope}
\fill[yshift=-4cm,xshift=-1.7cm,green!70!black!50] (0,2) -- (0,0) --+ (1.5,0) --+ (1.5,.3) --+ (1.1,.3) --+ (1.1,.9) --+ (1.5,.9) --+ (1.5,1) -- (1.1,1) --+ (0,.7) --+ (.4,.7) --+ (.4,1) -- cycle;
\begin{scope}[xshift=-1.2cm,yshift=-5cm]
\draw[very thick,red!70!black,fill=red!70!black!80] (0,0) circle(.5);
\draw[very thick,red!70!black,fill=red!70!black!80] (.5,0) circle(.5);
\draw[red!70!black!80,fill=red!70!black!80] (0,0) circle(.5);
\draw[red!70!black!80,fill=red!70!black!80] (.5,0) circle(.5);
\end{scope}
\end{tikzpicture}
\end{document}
Here is the output:
