Efficient way to unnest (explode) multiple list columns in a pandas DataFrame

def explode(df, lst_cols, fill_value=''):
    # make sure `lst_cols` is a list
    if lst_cols and not isinstance(lst_cols, list):
        lst_cols = [lst_cols]
    # all columns except `lst_cols`
    idx_cols = df.columns.difference(lst_cols)

    # calculate lengths of lists
    lens = df[lst_cols[0]].str.len()

    if (lens > 0).all():
        # ALL lists in cells aren't empty
        return pd.DataFrame({
            col:np.repeat(df[col].values, df[lst_cols[0]].str.len())
            for col in idx_cols
        }).assign(**{col:np.concatenate(df[col].values) for col in lst_cols}) \
          .loc[:, df.columns]
    else:
        # at least one list in cells is empty
        return pd.DataFrame({
            col:np.repeat(df[col].values, df[lst_cols[0]].str.len())
            for col in idx_cols
        }).assign(**{col:np.concatenate(df[col].values) for col in lst_cols}) \
          .append(df.loc[lens==0, idx_cols]).fillna(fill_value) \
          .loc[:, df.columns]

Usage:

In [82]: explode(df, lst_cols=list('BCDE'))
Out[82]:
    A   B   C   D   E
0  x1  v1  c1  d1  e1
1  x1  v2  c2  d2  e2
2  x2  v3  c3  d3  e3
3  x2  v4  c4  d4  e4
4  x3  v5  c5  d5  e5
5  x3  v6  c6  d6  e6
6  x4  v7  c7  d7  e7
7  x4  v8  c8  d8  e8

Use set_index on A and on remaining columns apply and stack the values. All of this condensed into a single liner.

In [1253]: (df.set_index('A')
              .apply(lambda x: x.apply(pd.Series).stack())
              .reset_index()
              .drop('level_1', 1))
Out[1253]:
    A   B   C   D   E
0  x1  v1  c1  d1  e1
1  x1  v2  c2  d2  e2
2  x2  v3  c3  d3  e3
3  x2  v4  c4  d4  e4
4  x3  v5  c5  d5  e5
5  x3  v6  c6  d6  e6
6  x4  v7  c7  d7  e7
7  x4  v8  c8  d8  e8

pandas >= 0.25

Assuming all columns have the same number of lists, you can call Series.explode on each column.

df.set_index(['A']).apply(pd.Series.explode).reset_index()

    A   B   C   D   E
0  x1  v1  c1  d1  e1
1  x1  v2  c2  d2  e2
2  x2  v3  c3  d3  e3
3  x2  v4  c4  d4  e4
4  x3  v5  c5  d5  e5
5  x3  v6  c6  d6  e6
6  x4  v7  c7  d7  e7
7  x4  v8  c8  d8  e8

The idea is to set as the index all columns that must NOT be exploded first, then reset the index after.

---

It's also faster.

%timeit df.set_index(['A']).apply(pd.Series.explode).reset_index()
%%timeit
(df.set_index('A')
   .apply(lambda x: x.apply(pd.Series).stack())
   .reset_index()
   .drop('level_1', 1))


2.22 ms ± 98.6 µs per loop (mean ± std. dev. of 7 runs, 100 loops each)
9.14 ms ± 329 µs per loop (mean ± std. dev. of 7 runs, 100 loops each)