Getting distance between two points based on latitude/longitude

Update: 04/2018: Vincenty distance is deprecated since GeoPy version 1.13 - you should use geopy.distance.distance() instead!

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The answers above are based on the Haversine formula, which assumes the earth is a sphere, which results in errors of up to about 0.5% (according to help(geopy.distance)). Vincenty distance uses more accurate ellipsoidal models such as WGS-84, and is implemented in geopy. For example,

import geopy.distance

coords_1 = (52.2296756, 21.0122287)
coords_2 = (52.406374, 16.9251681)

print geopy.distance.geodesic(coords_1, coords_2).km

will print the distance of 279.352901604 kilometers using the default ellipsoid WGS-84. (You can also choose .miles or one of several other distance units).

Edit: Just as a note, if you just need a quick and easy way of finding the distance between two points, I strongly recommend using the approach described in Kurt's answer below instead of re-implementing Haversine -- see his post for rationale.

This answer focuses just on answering the specific bug OP ran into.

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It's because in Python, all the trig functions use radians, not degrees.

You can either convert the numbers manually to radians, or use the radians function from the math module:

from math import sin, cos, sqrt, atan2, radians

# approximate radius of earth in km
R = 6373.0

lat1 = radians(52.2296756)
lon1 = radians(21.0122287)
lat2 = radians(52.406374)
lon2 = radians(16.9251681)

dlon = lon2 - lon1
dlat = lat2 - lat1

a = sin(dlat / 2)**2 + cos(lat1) * cos(lat2) * sin(dlon / 2)**2
c = 2 * atan2(sqrt(a), sqrt(1 - a))

distance = R * c

print("Result:", distance)
print("Should be:", 278.546, "km")

The distance is now returning the correct value of 278.545589351 km.