How I can delete in VIM all text from current line to end of file?

:.,$d

This will delete all content from current line to end of the file. This is very useful when you're dealing with test vector generation or stripping.

dG will delete from the current line to the end of file

dCtrl+End will delete from the cursor to the end of the file

But if this file is as large as you say, you may be better off reading the first few lines with head rather than editing and saving the file.

head hugefile > firstlines

(If you are on Windows you can use the Win32 port of head)

Go to the first line from which you would like to delete, and press the keys dG