Chemistry - How is bromothymol blue synthetised?
Now a days, sulfonephthaleins can be prepared by reaction of readily available saccharin and the desired plenol compound (Ref.1 & Ref.2). In this method, active reagent, sulfobenzoic anhydride will be prepared in situ as depicted in following diagram:
In this method, it's described the preparation of phenolsulfonephthalein (Phenol Red). If you use thymol instead of phenol, you will get thymolsulfonephthalein, which can be subsequently brominated by bromine/acetic acid to obtain dibromothymolsulfonephthalein (Bromothymol Blue). This procedure is described in Ref.2.
References:
- V. H. Tillu, D. K. Dumbre, H. B. Borate, R. D. Wakharkar, V. R. Choudhary, "Solvent-Free One-Pot Synthesis of Sulfonephthaleins from Saccharin and Phenols," Synthetic Communications 2012, 42(8), 1101-1107 (https://doi.org/10.1080/00397911.2010.535946).
- B. S. Rao, J. B. Puschett, B. M. Karandikar, K. Matyjaszewski, "Synthesis of Functional Bromothymol Blue Dyes for Surface Attachment to Optical Fibers," Dyes and Pigments 1991, 16(1), 27-34 (https://doi.org/10.1016/0143-7208(91)87018-I).