How to change column width in DataGridView?

You could set the width of the abbrev column to a fixed pixel width, then set the width of the description column to the width of the DataGridView, minus the sum of the widths of the other columns and some extra margin (if you want to prevent a horizontal scrollbar from appearing on the DataGridView):

dataGridView1.Columns[1].Width = 108;  // or whatever width works well for abbrev
dataGridView1.Columns[2].Width = 
    dataGridView1.Width 
    - dataGridView1.Columns[0].Width 
    - dataGridView1.Columns[1].Width 
    - 72;  // this is an extra "margin" number of pixels

If you wanted the description column to always take up the "remainder" of the width of the DataGridView, you could put something like the above code in a Resize event handler of the DataGridView.

In my Visual Studio 2019 it worked only after I set the AutoSizeColumnsMode property to None.

Set the "AutoSizeColumnsMode" property to "Fill".. By default it is set to 'NONE'. Now columns will be filled across the DatagridView. Then you can set the width of other columns accordingly.

DataGridView1.Columns[0].Width=100;// The id column 
DataGridView1.Columns[1].Width=200;// The abbrevation columln
//Third Colulmns 'description' will automatically be resized to fill the remaining 
//space