How to configure an app to run correctly on a machine with a high DPI setting (e.g. 150%)?

Once you go past 100% (or 125% with the "XP-style DPI scaling" checkbox ticked), Windows by default takes over the scaling of your UI. It does so by having your app render its output to a bitmap and drawing that bitmap to the screen. The rescaling of that bitmap makes the text inevitably look fuzzy. A feature called "DPI virtualization", it keeps old programs usable on high resolution monitors.

You have to explicitly let it know that you can handle higher DPI settings by adding the <dpiAware> element to your manifest. The MSDN page is here but it isn't complete since it is omitting the UAC settings. Project + Add New Item, pick "Application Manifest File". Edit the manifest text or copy/paste this:

<?xml version="1.0" encoding="utf-8"?>
<assembly xmlns="urn:schemas-microsoft-com:asm.v1" manifestVersion="1.0" xmlns:asmv3="urn:schemas-microsoft-com:asm.v3" >
    <assemblyIdentity version="1.0.0.0" name="MyApplication.app"/>
    <trustInfo xmlns="urn:schemas-microsoft-com:asm.v2">
        <security>
            <requestedPrivileges xmlns="urn:schemas-microsoft-com:asm.v3">
                <requestedExecutionLevel level="asInvoker" uiAccess="false" />
            </requestedPrivileges>
        </security>
    </trustInfo>
    <asmv3:application>
        <asmv3:windowsSettings xmlns="http://schemas.microsoft.com/SMI/2005/WindowsSettings">
            <dpiAware>true</dpiAware>
        </asmv3:windowsSettings>
    </asmv3:application>
</assembly>

You can also pinvoke SetProcessDPIAware() in your Main() method, necessary for example if you deploy with ClickOnce:

    [STAThread]
    static void Main() {
        if (Environment.OSVersion.Version.Major >= 6) SetProcessDPIAware();
        Application.EnableVisualStyles();
        Application.SetCompatibleTextRenderingDefault(false);
        Application.Run(new Form1());             // Edit as needed
    }

    [System.Runtime.InteropServices.DllImport("user32.dll")]
    private static extern bool SetProcessDPIAware();

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UPDATE, this common need is finally a bit easier if you use VS2015 Update 1 or higher. The added manifest already has the relevant directive, just remove the comments.

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Keyword for search so I can find this post back: dpiAware

Applications can be developed in two different mode.

The first one is to declare our application to be non-DPI-aware (not declaring anything will default to this). In this case the operating system will render our application under the expected 96 DPI and then will do to the bitmap scaling that we discussed before. The result will be a blurry looking application, but with a correct layout.

The second option is to declare the application as DPI-aware. In this case the OS will not do any scaling and will let your application render according to the original DPI of the screen. In case of a per-monitor-DPI environment, your application will be rendered with the highest DPI of all the screens, then this bitmap will be scaled down to the proper size for each monitor. Downscaling results in a better viewing experience than upscaling but you might still notice some fuzziness.

If you want to avoid that, you must declare your application as per-monitor-DPI-aware. Then you must detect when your application is dragged across different monitors and render according to the DPI of the current one.

Declaring the DPI awareness is done in a manifest file.

refer the following link stackoverflow

Using .NET Framework 4.7 and Windows 10 Creators Update (1703) or newer you must do the following things to configure high DPI support for your Windows Form application:

Declare compatibility with Windows 10.

To do this, add the following to your manifest file:

<compatibility xmlns="urn:schemas-microsoft.com:compatibility.v1">
  <application>
    <!-- Windows 10 compatibility -->
    <supportedOS Id="{8e0f7a12-bfb3-4fe8-b9a5-48fd50a15a9a}" />
  </application>
</compatibility>

Enable per-monitor DPI awareness in the app.config file.

Windows Forms introduces a new System.Windows.Forms.ApplicationConfigurationSection element to support new features and customizations added starting with the .NET Framework 4.7. To take advantage of the new features that support high DPI, add the following to your application configuration file.

<System.Windows.Forms.ApplicationConfigurationSection>
  <add key="DpiAwareness" value="PerMonitorV2" />
</System.Windows.Forms.ApplicationConfigurationSection>

Important

In previous versions of the .NET Framework, you used the manifest to add high DPI support. This approach is no longer recommended, since it overrides settings defined on the app.config file.

Call the static EnableVisualStyles method.

This should be the first method call in your application entry point. For example:

static void Main()
{
    Application.EnableVisualStyles();
    Application.SetCompatibleTextRenderingDefault(false);
    Application.Run(new Form1());   
}

The advantage of this is the support for dynamic DPI scenarios in which the user changes the DPI or scale factor after a Windows Forms application has been launched.

Source: High DPI support in Windows Forms