How to create a self resizing grid of buttons in tkinter?

The grid weight method might not work when you use scrollbar (at least in Mac) , so while using it pack the widget and scrollbar inside a frame and then grid the frame instead.

@Vaughn Cato gave an excellent answer here. However, he has accidentally included a bunch of extraneous code in his example. Here is a cleaned up and more organized full example doing exactly what his example does.

from tkinter import *

#Create & Configure root 
root = Tk()
Grid.rowconfigure(root, 0, weight=1)
Grid.columnconfigure(root, 0, weight=1)

#Create & Configure frame 
frame=Frame(root)
frame.grid(row=0, column=0, sticky=N+S+E+W)

#Create a 5x10 (rows x columns) grid of buttons inside the frame
for row_index in range(5):
    Grid.rowconfigure(frame, row_index, weight=1)
    for col_index in range(10):
        Grid.columnconfigure(frame, col_index, weight=1)
        btn = Button(frame) #create a button inside frame 
        btn.grid(row=row_index, column=col_index, sticky=N+S+E+W)  

root.mainloop()

Screenshots:

When it first opens (small):

After you maximize the window:

You need to configure the rows and columns to have a non-zero weight so that they will take up the extra space:

grid.columnconfigure(tuple(range(60)), weight=1)
grid.rowconfigure(tuple(range(30)), weight=1)

You also need to configure your buttons so that they will expand to fill the cell:

btn.grid(column=x, row=y, sticky="news")

This has to be done all the way up, so here is a full example:

from tkinter import *

root = Tk()
frame = Frame(root)
root.rowconfigure(0, weight=1)
root.columnconfigure(0, weight=1)
frame.grid(row=0, column=0, sticky="news")
grid = Frame(frame)
grid.grid(sticky="news", column=0, row=7, columnspan=2)
frame.rowconfigure(7, weight=1)
frame.columnconfigure(0, weight=1)

#example values
for x in range(10):
    for y in range(5):
        btn = Button(frame)
        btn.grid(column=x, row=y, sticky="news")

frame.columnconfigure(tuple(range(10)), weight=1)
frame.rowconfigure(tuple(range(5)), weight=1)

root.mainloop()

To make the buttons expand when the window is maximized, try to modify the button.grid entry as follows:

btn.grid(column=x, row=y, sticky=N+S+E+W)