How to Disable Emacs elpy Vertical Guide Lines for Indentation?

You can disable highlight-indentation-mode for elpy-mode, by adding the following code to your emacs initialization.

(add-hook 'elpy-mode-hook (lambda () (highlight-indentation-mode -1)))

EDIT: changed nil to -1

Source

You can customize the variable elpy-modules to disable the "display indentation markers" module.