How to disable Transparent Huge Pages (THP) in Ubuntu 16.04LTS

Below 3 commands fix the issue over Ubuntu(14.x/16.x) and also make it persistent on system boots.

1. sudo apt-get install hugepages
2. sudo hugeadm --thp-never
3. sudo /bin/sed -i '$i /usr/bin/hugeadm --thp-never' /etc/rc.local

Install :

sudo apt install hugepages

Then run :

sudo hugeadm --thp-never

To persist the changes you can add this last command to /etc/rc.local

To disable Transparent Huge Pages (THP) permanently choose one of the following options:

1. Via GRUB options (preferred):

   Edit /etc/default/grub to add transparent_hugepage=never to the GRUB_CMDLINE_LINUX_DEFAULT option:

    GRUB_CMDLINE_LINUX_DEFAULT="transparent_hugepage=never quiet splash"
   

After that, run update-grub command. (Need reboot to take effect)

2. With rc.local:

Edit /etc/rc.local and put following script before exit 0

    if test -f /sys/kernel/mm/transparent_hugepage/enabled; then
       echo never > /sys/kernel/mm/transparent_hugepage/enabled
    fi

* To avoid reboot (as mentioned before), you can disable it by # echo never > /sys/kernel/mm/transparent_hugepage/enabled command.

Did you try this command:

sudo su
echo never > /sys/kernel/mm/transparent_hugepage/enabled

?

Alternatively, you may install hugepages

sudo su
apt-get install hugepages
hugeadm --thp-never

As mentioned by @Anthony, the effect would not persist after a reboot. Use your distribution-specific method to do that every time after reboot.