How to fix "spatial_ref_sys relation does not exist"

One other point that may help somebody else... Make sure you're actually in the database which has had the GIS extensions added before you try to grant privileges on it!

$ psql geodjango
psql (9.1.6)
Type "help" for help.

geodjango=# grant select,insert,update,delete on spatial_ref_sys to postgres;
GRANT

Did you also execute spatial_ref_sys.sql ?

You need to install postgis first. Then dont forget to create extension postgis on your database.

PSQL

\c gis; --Connect to gis database CREATE EXTENSION postgis;