How to force a web browser NOT to cache images

Armin Ronacher has the correct idea. The problem is random strings can collide. I would use:

<img src="picture.jpg?1222259157.415" alt="">

Where "1222259157.415" is the current time on the server.
Generate time by Javascript with performance.now() or by Python with time.time()

Simple fix: Attach a random query string to the image:

<img src="foo.cgi?random=323527528432525.24234" alt="">

What the HTTP RFC says:

Cache-Control: no-cache

But that doesn't work that well :)