How to perform a Hard Refresh in Edge?

Thanks to @Jimmery I found a setting.

Tried Ctrl+R but it does not bypass cache

You need to Open Developer Tools (Ctrl+Shift+I) and when you right click the refresh button you have more refresh options like Ctrl+Shift+R to Reload the current page, ignoring cached content and another one to clear cache and refresh.

https://support.microsoft.com/en-us/help/4531783/microsoft-edge-keyboard-shortcuts