How to run C# Desktop Application with extension .exe in Mac OSX?

You should use the following command line:

mono my_cool_program.exe

yes this is working fine for run exe file...

open terminal ...

then write mono on terminal and copy exe file path and past after mono, then your exe file execute...

apple-pc:~ Santosh$ mono /Users/Santosh/Downloads/Myapp/bin/Debug/Myapp.exe

I think you will have to install Mono Runtime on target machine.

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