How to 'update' or 'overwrite' a python list

You may try this

alist[0] = 2014

but if you are not sure about the position of 123 then you may try like this:

for idx, item in enumerate(alist):
   if 123 in item:
       alist[idx] = 2014

What about replace the item if you know the position:

aList[0]=2014

Or if you don't know the position loop in the list, find the item and then replace it

aList = [123, 'xyz', 'zara', 'abc']
    for i,item in enumerate(aList):
      if item==123:
        aList[i]=2014
        break
    
    print aList

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